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(Claimed. I really need to save my credentials on my phone.)
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[@Barhandar":](/forums/dis/topics/video-game-thread?post_id=45071#post_45071
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You can, if you buy a screwdriver set with tri-wing heads or you're lucky enough to have the tri-wing driver that came with DSi battery replacements - Nintendo swapped to tri-wings some time after the NES era. But at that point you're spending more money to play the game. Unless you really care about portability, emulation carries a number of benefits over native: color adjustment (important for GBA games to combat oversaturation that was baked in to counter the backlight), greater screen resolution, control options, netplay (for legacy games that used corded/wireless non-WiFi adapters), no contacts to keep clean, no worry about system battery life, and no chance of misplacing your cartridge.
EDIT: OH, add another benefit - emulation of failed hardware. In the example of the first two Boktai games, the solar sensors on the cartridge heads had a bad habit of burning out and cannot be replaced without soldering micro-components, which carries a risk of burning out other components. Most modern emulators or libretro cores have specific emulation routines for these hardware gimmicks.