Original Description:
A little explanation for non-Russian speakers:
This is a spoof of a famous Soviet anti-alcohol poster that depicts a man firmly rejecting a shot of vodka.
The text says “No! The Great and Powerful Trixie does not trust wheels!”
The joke here is that in Russian any drug in form of pills can be referred to as “wheels” (just like marijuana is often referred to as “weed”), and Trixie does not trust wheels! Get it? Huh? HUH?!