He does not care for any of his sisters. Love Letter is afraid of him and will try to avoid him. Marigold is quite the opposite allways wanting to help by bringing him stuff. Or just hanging around him asking what he’s doing. Inkwell hates it. Marigold also keeps calling him “Big brother” and “Inky”, both names which he despises, especially when their coming from her (If it where up to him he would decide that he didn’t have any sisters).
Another reason for demanding being left alone is partly because of his research not always being very… “good” or even “legal”, so the less nosy ponies the better.