Artist comment:  
“i doubt anyone else made something like this before  
now first let me tell you, i watched the episode of teen titans go “boys vs girls”, and robin giving raven and starfire cooties actually inspired me to make this quadruple character vector  
so now pinkie pie, twilight, and rarity are ridden with cooties, and they all want to give it to spike  
i guess you can say this is what could happen to spike when he tries to prove to the ponies that boys ’re better than girls and he actually brings out the theory that girls have cooties, especially because his friends are all girls  
you may also say spike could do the exact same thing robin did, create a potion that gives the girls cooties for real and they give it to him as well  
so yeah, what do you think? “